This work seeks to expose the effects of social factors on human life in Nigeria. Man is a social being and must live in a society with others. In Nigeria, like in every human society, certain social factors affect the quality of life of the members of that society. The effects of such factors can be physical, psychological, emotional, etc. This work begins with an introduction and goes on to clarify some important terms. Next, it discusses the theological foundations for human life and dignity. One by one, it discusses how social actors affect human life in Nigeria: economy, security, infrastructure, environment, education, healthcare, social and cultural issues. Finally, it proposes such lines of action as promoting education, security measures, economic development, good governance, social cohesion, gender equality and cultural values. It is hoped that if intentional and deliberate efforts are made towards addressing the issues raised in this article, human life and dignity will be better protected and the quality of life of the average Nigerian will be improved.