Presently, Nigeria is in crisis. An obvious challenge to peace and unity in Nigeria is the intrusion of politics into religion. Religion becomes an instrument for political manipulation. A crisis may start as a political conflict but develops into a religious crisis. The main aim of this research is to analyze the involvement of politics in religion that causes crises and ways to resolve them. The research approach is Descriptive analysis. The data obtained was subjected to critical analysis. Findings show that in Nigeria, politics is mostly associated with corruption, manipulation and creating violence for personal gain, which are contrary to morals preached by religions. The research recommends, among others, that there should be a paradigm shift from politics of domination and manipulation to love, moral soundness and genuine service in politics. These will enhance good interactions between politics and religion in Nigeria. The research will benefit the government and Nigerians who desire peace and unity in Nigeria.