The paper explored the Domestic Environment and Nigeria's International Relations. The need to address domestic issues which usually arise from the domestic environment of states is the driving force behind interactions between and among states. Foreign policy is the projection of the national interest of a state in the global system. Nigeria is mired with numerous domestic problems such as insecurity, infrastructural decay general underdevelopment etc. These amongst others form the locus of her engagement with other states in the international system. The study adopted the realist theory propounded by Hans J. Morgenthau in 1948 as its theoretical framework. It situated Nigeria's interactions with other states in the global system within the context of her national interest. The secondary source of data was applied for the study; it involves the collection of data from textbooks, articles, seminar papers, journals etc. The study observed that interactions between and among states in the global system are inevitable because no state is an island of its own. The study recommends that the Nigerian government should appoint people who have vast knowledge about Nigerian foreign policy to man the Ministry of Foreign Affairs to help give direction to the formulation and implementation of policies that reflect the domestic needs of Nigeria in the international arena.